Genitourinary Syndrome of Menopause (GSM) refers to a collection of signs and symptoms of the female genital tract and urinary system that are caused by the fluctuation and decline of reproductive hormones. GSM affects the bladder, vagina, vulva and clitoris, and despite being very common it is largely under reported due to embarrassment and lack of awareness or education about the condition.
Although this term references menopause, it is important to recognise that symptoms can arise during other times of hormonal fluctuation such as during breastfeeding, during and post cancer treatment such as pelvic radiation and chemotherapy, progestin-only contraceptive use and other anti-estrogenic therapies.
GSM is a physically, psychologically and socially debilitating condition that can have a significant impact on quality of life and significantly contribute to healthcare economic burden. For example women are 3 times more likely to get a UTI post menopause. UTIs can increase the risk of confusion, falls, fractures, sepsis and ultimately death.
It is important to recognise the signs and symptoms, so the appropriate advice and treatment can be initiated.
Estrogen stimulates glycogen production in the vaginal lining. This glycogen provides fuel for the healthy bacteria that colonise the genitourinary tract, which in turn produce lactic acid keeping the vaginal pH low and the environment balanced.
As estrogen declines, glycogen levels fall, healthy bacteria reduce, and less lactic acid is produced. This leads to a higher vaginal pH, which can contribute to dryness, irritation, and an increased risk of urinary tract infections.
Estrogen also helps maintain healthy, well-lubricated tissues. It supports collagen and elastin production, which keeps tissues strong, resilient, and stretchy. Without enough estrogen, tissues can become thinner, drier, and more prone to micro-tears.
In addition, estrogen supports blood flow to the genitourinary system, improving oxygen delivery to tissues and helping maintain sexual response. In the bladder, it helps preserve mucosal thickness, vascularity, and receptor sensitivity, which is why urinary frequency, urgency, and discomfort can become more common during menopause.
It also plays a role in pelvic floor muscle function by supporting connective tissue integrity and neuromuscular health. When estrogen levels fall, the risk of prolapse can increase.
The genitourinary tract is also influenced by androgens such as testosterone that have similar function to estrogen but a different mechanism of action. Testosterone can help with tissue health and sexual function and not surprisingly, there is a high number of androgen receptors around the clitoris, vaginal opening and lower part of the vagina. Testosterone increases nerve density and function, increasing sexual arousal and pleasure. It is also involved in supporting blood flow, tissue integrity and production of lubrication.
The first step to treatment is an open honest discussion with your healthcare provider, so you receive appropriate advice and treatment.
Download your free factsheet.
The Role of Hormones in Genitourinary Health – A comprehensive resource exploring how hormonal changes influence vaginal, vulval, and urinary health during midlife, with practical advice, treatment options, and support strategies to improve quality of life.
Vaginal & Urinary Symptoms in Midlife – Explore the hormonal changes that can affect vaginal and urinary health during menopause, including symptoms, risk factors, and strategies to improve comfort and wellbeing.
Sexual Pain Worksheet – record your answers and discuss with your GP.
You Are Not Broken– Kelly Casperson MD
The Menopause Moment– Kelly Casperson MD
Where Did My Libido Go?– Dr Rosie King
The M Word– Dr Ginni Mansberg
Disclaimer: This content is for informational purposes only and does not constitute medical advice or a clinical consultation. Always discuss your symptoms and treatment options with a qualified health professional for an individualised assessment and recommendations.
Persistent dryness, burning, irritation, tightness, or discomfort during everyday activities or intimacy.
Decreased lubrication and tissue thinning can cause irritation, dryness, pain on sitting or during activities as well as painful intercourse (dyspareunia).
Avoid irritants, such as:
In milder cases of vaginal dryness, it may be sufficient to use vaginal moisturisers and lubricants to treat the symptoms, however this does not treat the underlying cause of low hormones. In Australia, vaginal hormone preparations are prescription-only and should be discussed with a doctor or nurse practitioner.
Please note: Vaginal estrogens are a very safe and effective treatment for menopausal vaginal dryness and GSM; they may even be used after breast cancer (after discussion with the cancer specialists). They are localised topical treatments only and are not absorbed measurably into the bloodstream so they do not treat systemic symptoms like hot flushes.
A stinging, burning sensation inside or around the vagina, often worse with sex, peeing, or touching the area. May come with itching, rawness, or sensitivity that makes daily activities uncomfortable.
Burning & irritation may be caused by infections, underlying conditions such as lichen sclerosis or reactions to irritants in addition to low hormones.
Antibiotics for bacterial vaginosis
Stronger antifungals for recurrent or resistant thrush
Treatment for STIs if relevant
Antibiotics for urinary tract infection
Vaginal estrogen cream: Applied inside the vagina to improve tissue thickness and moisture
Vaginal estrogen pessary/tablet: A small pessary placed into the vagina, containing a form of low-dose oestrogen
Vaginal DHEA (dehydroepiandrosterone) pessary: A pessary containing DHEA that once inserted in the vagina, the vaginal cells will convert the DHEA into estrogen and androgens, such as testosterone
Systemic hormone therapy: May be considered if vaginal dryness occurs alongside hot flushes or other menopausal symptoms. This may be given as tablets, patches, or gels
Specialist review if symptoms persist, as some chronic or pre-cancerous conditions may cause similar symptoms
See your doctor promptly if symptoms persist or worsen, you have discharge/ odour/ fever, or suspect you have a urinary tract infection, a sexually transmitted disease, recurrent thrush or bacterial vaginosis.
Persistent urge to scratch inside or around the vagina or vulva, and perhaps even the anus. It can range from mild tickling to intense irritation that disrupts sleep or daily life and is often worse at night or after sweating.
Low estrogen (menopause), yeast infections (thrush), bacterial vaginosis, allergies to soaps/pads/perfumes, skin conditions (lichen sclerosus, eczema), hormonal changes (PCOS), or sexually transmitted infections.
Sharp or burning pain at the entrance, deep ache with thrusting, or soreness that lasts for some time after sex. It can make you tense up or avoid intimacy.
Low estrogen (menopause, breastfeeding), vaginal dryness and tissue thinning, infections (thrush, BV), pelvic floor tension, endometriosis, vaginismus (involuntary vaginal muscle tightening), allergies to products or condoms, or insufficient arousal/foreplay. Sexual pain is a complex issue, and some causes can be more serious; check out our full article here for more information.
See your doctor if: Pain persists despite lubrication, new bleeding/discharge, you have deep pelvic pain, a history of sexual trauma or violence, suspect an STI or are unable to have penetrative sex.
Not everyone has all these symptoms, but they can include intense vaginal itching (especially at night), thick white “cottage cheese” discharge, redness/swelling of vulva, soreness or burning with sex or peeing. Episodes return frequently despite treatment.
Recurrent thrush is four or more episodes per year of vaginal fungal overgrowth (Candida albicans most common). Risk factors include low estrogen, antibiotics, high blood sugar or diabetes, tight clothing, pregnancy, hypersensitive immune response, or atypical yeast strains.
See your doctor if: you have many episodes per year, symptoms persist despite treatment, unusual discharge or odour, pain, diabetes symptoms, or pregnancy. They may test for resistant yeast or underlying causes.
Small leaks when coughing, sneezing, laughing or exercising (stress leakage), sudden uncontrollable gush before reaching the toilet (urge leakage), or constant dribbling (overflow). Can feel embarrassing and limit activities.
Weak pelvic floor muscles (childbirth, menopause), low estrogen thinning urethral tissue, overactive bladder, obesity, chronic cough, constipation, prolapse, or neurological conditions.
This is an incredibly common symptom, with leakage and other continence issues affecting more than half of postmenopausal women. It can be debilitating and keep women restricted in even leaving the house or going about their daily activities.
See your doctor if: leakage affects quality of life, sudden worsening, blood in urine, pelvic pain or prolapse symptoms. Pelvic floor assessment recommended.
Sudden strong urge to pee that’s hard to ignore, needing to go more often than usual (8+ times/day), waking multiple times at night (nocturia), or leaking a little before you reach the toilet.
Low estrogen (such as GSM, causing bladder and urethral tissue thinning and bladder irritability), overactive bladder, urinary tract infections (UTIs), pelvic floor weakness, diabetes/high blood sugar, caffeine or alcohol excess, overhydration, constipation, certain medications or anxiety/stress.
See your doctor if: Leaking with urgency, blood in urine, fevers, chills, symptoms lasting over 2 weeks, or diabetes symptoms. Urine tests may be needed.
Persistent dryness, burning, irritation, tightness, or discomfort during everyday activities or intimacy.
Decreased lubrication and tissue thinning can cause irritation, dryness, pain on sitting or during activities as well as painful intercourse (dyspareunia).
Avoid irritants, such as:
In milder cases of vaginal dryness, it may be sufficient to use vaginal moisturisers and lubricants to treat the symptoms, however this does not treat the underlying cause of low hormones. In Australia, vaginal hormone preparations are prescription-only and should be discussed with a doctor or nurse practitioner.
Vaginal estrogens are a very safe and effective treatment for menopausal vaginal dryness and GSM; they may even be used after breast cancer (after discussion with the cancer specialists). They are localised topical treatments only and are not absorbed measurably into the bloodstream so they do not treat systemic symptoms like hot flushes.
A stinging, burning sensation inside or around the vagina, often worse with sex, peeing, or touching the area. May come with itching, rawness, or sensitivity that makes daily activities uncomfortable.
Burning & irritation may be caused by infections, underlying conditions such as lichen sclerosis or reactions to irritants in addition to low hormones.
Burning & irritation may be caused by infections or reactions to irritants in addition to low hormones.
For infections:
Antibiotics for bacterial vaginosis
Stronger antifungals for recurrent or resistant thrush
Treatment for STIs if relevant
Antibiotics for urinary tract infection
Vaginal estrogen cream: Applied inside the vagina to improve tissue thickness and moisture
Vaginal estrogen pessary/tablet: A small pessary placed into the vagina, containing a form of low-dose oestrogen
Vaginal DHEA (dehydroepiandrosterone) pessary: A pessary containing DHEA that once inserted in the vagina, the vaginal cells will convert the DHEA into estrogen and androgens, such as testosterone
Systemic hormone therapy: May be considered if vaginal dryness occurs alongside hot flushes or other menopausal symptoms. This may be given as tablets, patches, or gels
Specialist review if symptoms persist, as some chronic or pre-cancerous conditions may cause similar symptoms
See your doctor promptly if symptoms persist or worsen, you have discharge/ odour/ fever, or suspect you have a urinary tract infection, a sexually transmitted disease, recurrent thrush or bacterial vaginosis.
Persistent urge to scratch inside or around the vagina or vulva, and perhaps even the anus. It can range from mild tickling to intense irritation that disrupts sleep or daily life and is often worse at night or after sweating.
Low estrogen (menopause), yeast infections (thrush), bacterial vaginosis, allergies to soaps/pads/perfumes, skin conditions (lichen sclerosus, eczema), hormonal changes (PCOS), or sexually transmitted infections.
Sharp or burning pain at the entrance, deep ache with thrusting, or soreness that lasts for some time after sex. It can make you tense up or avoid intimacy.
Low estrogen (menopause, breastfeeding), vaginal dryness and tissue thinning, infections (thrush, BV), pelvic floor tension, endometriosis, vaginismus (involuntary vaginal muscle tightening), allergies to products or condoms, or insufficient arousal/foreplay. Sexual pain is a complex issue, and some causes can be more serious; check out our full article here for more information.
See your doctor if: Pain persists despite lubrication, new bleeding/discharge, you have deep pelvic pain, a history of sexual trauma or violence, suspect an STI or are unable to have penetrative sex.
Not everyone has all these symptoms, but they can include intense vaginal itching (especially at night), thick white “cottage cheese” discharge, redness/swelling of vulva, soreness or burning with sex or peeing. Episodes return frequently despite treatment.
Recurrent thrush is four or more episodes per year of vaginal fungal overgrowth (Candida albicans most common). Risk factors include low estrogen, antibiotics, high blood sugar or diabetes, tight clothing, pregnancy, hypersensitive immune response, or atypical yeast strains.
See your doctor if: you have many episodes per year, symptoms persist despite treatment, unusual discharge or odour, pain, diabetes symptoms, or pregnancy. They may test for resistant yeast or underlying causes.
Small leaks when coughing, sneezing, laughing or exercising (stress leakage), sudden uncontrollable gush before reaching the toilet (urge leakage), or constant dribbling (overflow). Can feel embarrassing and limit activities.
Weak pelvic floor muscles (childbirth, menopause), low estrogen thinning urethral tissue, overactive bladder, obesity, chronic cough, constipation, prolapse, or neurological conditions.
This is an incredibly common symptom, with leakage and other continence issues affecting more than half of postmenopausal women. It can be debilitating and keep women restricted in even leaving the house or going about their daily activities.
See your doctor if: leakage affects quality of life, sudden worsening, blood in urine, pelvic pain or prolapse symptoms. Pelvic floor assessment recommended.
Sudden strong urge to pee that’s hard to ignore, needing to go more often than usual (8+ times/day), waking multiple times at night (nocturia), or leaking a little before you reach the toilet.
Low estrogen (such as GSM, causing bladder and urethral tissue thinning and bladder irritability), overactive bladder, urinary tract infections (UTIs), pelvic floor weakness, diabetes/high blood sugar, caffeine or alcohol excess, overhydration, constipation, certain medications or anxiety/stress.
See your doctor if: Leaking with urgency, blood in urine, fevers, chills, symptoms lasting over 2 weeks, or diabetes symptoms. Urine tests may be needed.
It is important to remember that there are many other causes of vulvovaginal symptoms like itching and pain, for example infections and skin conditions (some of which may be quite serious). Don’t assume that because you are menopausal it must be GSM, especially if treatments aren’t working. You should see your GP for an examination prior to starting any treatment.
If you can’t find the professional help you need for your menopausal symptoms then book a Telehealth consultation today with an expert WellFemme menopause doctor.
If you are curious about hormonal treatments, check out our detailed information and resources HERE, more signs & symptoms of menopause, and Peri & Menopause Symptoms: What Works?
Currently there is insufficient evidence to support the use of vaginal laser therapy for GSM.